When you're trying on your running shoes, make sure you consider the socks at the same time. Depending upon the thickness of the socks (thin or thick), it can affect the fit of the shoe. Remember too that your foot will swell as you run, so you don't want thick socks with a tightly fitting shoe. That will just lead to trouble.
The typical cotton socks that may be in your drawer can cause problems for you if you try to run in them. Cotton absorbs moisture without wicking it away from your feet, and this will practically guarantee that you will get blisters. Instead look at socks that have wool, synthetics or a blend of the two to keep your feet dry and comfortable. Some socks have a dual layer of materials - the first to wick away the sweat, the second to provide padding for your feet.
Running socks that are made from Merino wool or have a blend with Merino wool naturally resist odors. This can help you keep your shoes longer so they don't get too smelly after long runs.
Consider your running style too when making a decision about thicker socks versus thinner socks. If you're into running during the winter, you may need to purchase some heavier socks during the cold weather. Thinner socks can help during the hotter summer months too. If you're into trail running or where there may be mud, make sure you get a good pair of socks that can withstand the moisture, wicking it away, and still keep you comfortable.
Finally, make sure the sock fits both your foot and the type of shoe you're wearing. Minimalist shoes don't need socks to go as high up on your foot, but you want to protect your ankle and heel if you're wearing a taller shoe. Furthermore, running socks aren't a "one-size-fits-all" like regular socks typically are. Get the correct size for you. If you have too much sock material, it can bunch up or slip causing blisters. If your socks are too small, it can lead to lack of circulation.
If you have questions, be sure to ask the experts at the Mosaic City Sports and they will be happy to help you pick out the best running socks and running shoes to fit your style.